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Why can't patients who use glucocorticoid drugs for a long time and a lot of drugs stop suddenly?

发布时间：2025-10-08 09:20:55

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答案：【计分规则】: When a large volume of glucocorticoid is used for a long time, the concentration of exogenous glucocorticoids in the blood increases, which can feedback inhibit the secretion of ACTH from the pituitary gland, meanwhile the reactivity of the pituitary gland to CRH also weakens. As a result, the blood ACTH level significantly reduce. ACTH can not only promote the secretion of glucocorticoids, but also be necessary to maintain and stimulate the growth and development of the cells of the adrenal cortical tract and reticulum. Therefore, the reduction of ACTH levels in the blood will cause the cells of the adrenal cortical tract and reticular zone to gradually shrink, therefore, the endogenous glucocorticoid secretion decreases.(5`)If the patient suddenly stops taking the drug, after losing the support of exogenous glucocorticoids, the level of glucocorticoids in the blood will suddenly decrease due to insufficient self-secretion, and result in a series of symptoms of corticosteroid deficiency, such as blood glucose decreases, blood pressure decreases, nerve systemic excitability decreases and decreased resistance to damaging stimuli, especially the body's reaction due to stress is weakened, tolerance and resistance to noxious stimuli are weakened as well, and adrenal crisis occurs, which may be life-threatening in severe cases .(5)